Product Description of 4'-Hydroxyacetophenone CAS#99-93-4
4'-Hydroxyacetophenone (CAS-No.99-93-4) is an essential fine-chemical intermediate with the molecular formula C8H8O2 and a molecular-weight value of 136.15. Under normal temperature and atmospheric pressure, it generally exists as white-to-light-beige crystalline solids with a faint sweet-scented odour. The substance dissolves readily in hot water, methanol, ethyl ether and acetone, while showing poor solubility in cold-water solvents. Being a multi-functional chemical feedstock, it occupies a vital position within numerous industrial sectors.
4'-Hydroxyacetophenone Chemical Properties
| Melting point | 132-135 °C(lit.) |
| Boiling point | 147-148 °C3 mm Hg(lit.) |
| density | 1.109 |
| vapor pressure | 0.002Pa at 20℃ |
| refractive index | 1.5577 (estimate) |
| FEMA | 4330 | 4-HYDROXYACETOPHENONE |
| Fp | 166 °C |
| storage temp. | Store below +30°C. |
| solubility | methanol: 0.1 g/mL, clear |
| form | Crystalline Powder |
| pka | 8.05(at 25℃) |
| color | White to beige |
| Specific Gravity | 1.109 |
| Odor | at 10.00 % in dipropylene glycol. mild sweet hawthorn balsam mimosa |
| Odor Type | floral |
| Water Solubility | 10 g/L (22 ºC) |
| JECFA Number | 2040 |
| BRN | 774355 |
| InChIKey | TXFPEBPIARQUIG-UHFFFAOYSA-N |
| LogP | 1.35 at 25℃ |
| CAS DataBase Reference | 99-93-4(CAS DataBase Reference) |
| NIST Chemistry Reference | Acetophenone, 4'-hydroxy-(99-93-4) |
| EPA Substance Registry System | 4-Hydroxyacetophenone (99-93-4) |
| Hazard Codes | Xn,Xi |
| Risk Statements | 36/37/38-22 |
| Safety Statements | 26-36/37-37/39-24/25-22-36 |
| WGK Germany | 3 |
| RTECS | PC4959775 |
| Hazard Note | Irritant |
| TSCA | Yes |
| HS Code | 29145000 |
Product Application of 4'-Hydroxyacetophenone CAS#99-93-4
4'-Hydroxyacetophenone works as a versatile heterocyclic-free synthetic intermediate across fine-chemical industries. Benefiting from the reactive ketone and phenolic-hydroxyl groups on its benzene ring, it participates in abundant substitution reactions to prepare diversified downstream chemicals.
Its major usage lies in the production of choleretic medicines, antipyretic-analgesic preparations and related pharmaceutical precursors such as α-bromo-p-hydroxyacetophenone. Apart from drug-making workflows, the compound is processed into perfume raw materials, crop-protection intermediates and dyestuff additives. It can also serve as a basic ingredient for developing functional feed additives and liquid-crystal raw materials in material-science research.
